Umar Iqbal, Sadia Nosheen, Muhammad Aslam Khan, Muhammad Sohail Bashir, Ghazala, Fatima Naumeri, Zahid Kamal, Mustehsan Bashir.
Comparison of Effectiveness of Propranolol with Prednisolone in the Treatment of Infantile Hemangioma.
Pak Paed J Jan ;45(4):463-73.

Objective: Multiple treatment modalities have been used to treat infantile hemangioma, among which oral prednisolone and propranolol are the leading one. Our objective was to conduct a randomized control trial to compare the outcome of both drugs. Study Design: Randomized control trial was conducted on total of 56 patients, 28 in each group. Place and Duration of Study: The study was conducted in the department of plastic and reconstructive surgery, Mayo Hospital, Lahore and the total duration was two years. Material and Methods: After randomization, oral propranolol was given to one group in a dose of 2 mg/kg/day in three divided doses and oral prednisolone was given to the other group in the dose of 3 mg/kg/day as a single dose in the morning. Outcome after 6 months was measured in terms of percentage reduction in size and cosmetic outcome assessed by blinded plastic surgeon. Results: Our results showed higher percentage reduction of size of the lesion in propranolol group as compared with the prednisolone group with p-value of 0.001 which is statistically significant. When assessed by the blinded plastic surgeons, propranolol group showed significantly higher satisfaction rate as compared with the prednisolone group (p-value = 0.033). Conclusion: Oral propranolol is a better first line therapy as compared with prednisolone in the treatment of infantile hemangioma, in terms of percentage reduction in size of the lesion and surgeon`s satisfaction.

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