Muhammad Hanif Memon, Shahina Hanif, Farhan Saeed, Erum Saboohi, Saeeda Fouzia Qasim, Nayab Afzal.
Adverse Neonatal Outcomes of Prolonged Latency after Premature Rupture of Membranes (PROM).
Pak Paed J Jan ;46(1):9-14.

Objective: To determine the association of prolonged duration of latency after premature rupture of membranes (PROM) and adverse neonatal outcomes. Study Design : Cross sectional study Place and Duration of Study: Karachi Adventis Hospital, 3 months Material and Methods: A total of 155 full-term neonates born after 18 hours of premature rupture of membrane were selected. Neonates were divided into two groups of 18-24 hours and >24 hours based on duration of latency. After delivery gender, birth weight, heart rate, respiratory rate, APGAR score at 5th minute, need for resuscitation and umbilical cord compression, NICU admission or death were noted. Blood samples were sent to laboratory. Multivariate logistic regression analysis was done to find out the association between duration of latency after PROM and adverse outcomes. Odd ratio was calculated. P value <0.05 was considered as statistically significant. Result: The mean duration of latency was 29.7 + 10.69 hours. Duration of latency was 18-24 hours in 80(51.6%). 86 (55.5%) were male. Multivariate logistic regression analysis showed that risk of APGAR score <7 at 5th minute was 1.9 times, sepsis 3.4 times, hypoglycemia 6.1 times, need for resuscitation 7.1 times, NICU admissions 2.08 times and mortality was 4.1 times higher in neonates born following latency >24 hours. Conclusion: It can be concluded that prolonged latency duration of > 24 hours after PROM is associated with a considerable increase in adverse neonatal outcomes like decreased APGAR score, sepsis, hypoglycemia, NICU admission, need for resuscitation, and mortality.

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