Ari M Af, Hussain M S, Hashmi K.
Sensitivity and response to various drugs in children with Enteric Fever.
Pak Paed J Jan ;24(4):127-33.
Objectives:- Enteric fever is endemic in Pakistan. Development of multi drug resistant strains of salmonella typhi and irrational use of second line drugs are posing considerable problems in management. Therefore it is important to study local antibiotic sensitivities and alternate treatment modules. Methods:- A prospective study was carried out on seventy eight, blood/bone marrow culture positive patients for salmonella typhi ranging in age from 1 month to 13 years. Results:- Blood/bone marrow cultures were positive for salmonella typhi in seventy eight (60.09%) out of 128 patients tested for suspected enteric fever or septicemia. The organism showed good sensitivity of ceftazidime, ceftriaxone and oflozacin (89100%), while sensitivity to chloramphenicol, ampicillin and amozicillin was 36-48%. Conclusions:- Chloramphenicol, ampicillin and amoxicillin are likely to be effective in less than 50% of cases. Ceftriaxone and ceftazidime, equally effective, in about 90% while oflozacin is effective in nearly 100% of cases.
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