Fariha Muzammil, Zobia Mushtaq, Hamza Muzammil, Zareen Amjad, Abdul Wassae.
Interferon induced oxidative stress in chronic hepatitis C patients.
J Allama Iqbal Med Coll Jan ;19(4):927-31.

Objective: Objective of our study was to asses oxidant status of patients with chronic hepatitis C and the effect of pegylated interferon alpha plus ribavirin combination treatment on oxidative stress. Methods: This cross-sectional study was done in Sahiwal medical college and allied hospitals from May2021 to September 2021. Serum and saliva samples of thirty patients of HCV on IFN therapy and thirty age and sex matched controls were selected for the current study. MDA and Isoprostanes were assayed to assess oxidative stress caused by therapy. Results: The samples obtained from HCV patients showed statistically Significant (P=0.014) higher level of MDA in serum (3.29±0.465nmol/ml) and saliva (0.182±00065nmol/ml) of patients in comparison with normal individual's serum (0.91±0.027nmol/ml) and saliva (0.0215±0.005nmol/ml). An overall highly significant increasing trend was also observed between HCV patients and controls (p=0.000, p=0.011) as the mean levels of isoprostanes and 8-OHdG in control's serum (0.79±0.036pg/ml, 0.034±0.001ng/ml) and saliva (0.001±0.0005pg/ml, 0.0013±0.0004ng/ml) and patient's serum (4.319±3.09pg/ml, 1.06±0.046ng/ml) and saliva (0.29±0.019pg/ml, 0.026±0.0014ng/ml) were observed respectively. Conclusion: Patients of HCV who received the IFN therapy show increased lipid peroxidation and oxidative stress. Levels of MDA, 8-OHdG and Isoprostanes in serum and saliva of subjects were higher when they were compared with the controls which helped us to bring about a conclusion that IFN may serve as a reason for increased lipid peroxidation and oxidative stress in hepatitis C patients under treatment.

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