Muhammad Imran, Mussarat Rafiq, Syeda Eisha Hamid, Zaman Gul, Hafiza Nabeela Amaan, Muhammad Babar Khawar.
Estimation of Physicochemical Properties and Antioxidant Activity of Root Extract of Physalis minima.
RADS J Pharm Pharmaceut Sci Jan ;9(3):175-84.

Background: Physalis minima is used in a variety of ailments. Although, there have been a few studies on the leaves and fruits of the Physalis minima, there have been relatively few investigations on the roots. Objectives: The objective of the present study is to investigate the physicochemical parameters, trace elements, FTIR, and antioxidant activity of Physalis minima root extracts. Methodology: Standard procedures were used to conduct these studies on n-Hexane, chloroform, and methanolic extracts of roots. The antioxidant activity was performed by standard procedures as DPPH (2, 2-diphenyl-1-picrylhydrazyl), phosphomolybdenum method, FRAP (ferric reducing antioxidant power assay), and hydrogen peroxide scavenging activity. Results: Phytochemical analysis showed moisture content as 4.93 +- 0.98%, total ash 10.09 +- 0.76%, sulfated ash 4.92 +- 0.91%, acid insoluble ash 4.3 +- 0.88%, water-soluble extractive value 4.60 +- 0.01%, and alcohol soluble extractive value 17.92 +- 0.01%. FTIR analysis showed the presence of alkyl, amino, and tertiary alcohol groups. Percentage scavenging activity was measured by DPPH method and it was found that methanol extract showed maximum 93.525 +- 0.276% scavenging activity as compared to chloroform 60.248 +- 0.847%, and n-hexane 50.0 +- 0.547%. Phosphomolybdenum assay showed maximum potential 86.81 +- 0.521% in the methanolic extract, 60.07 +- 0.645% in chloroform extract, and 49.33 +- 0.841% in n-hexane extract. FRAP showed maximum reducing value for methanol extract 86.153 +- 0.203%, in chloroform 47.180 +- 0.352%, and n-hexane extract 30.26 +- 0.703%. By hydrogen peroxide assay, methanol extract possesses a maximum percentage of inhibition 91.71 +- 0.992%, chloroform extract 60.64 +- 0.721%, and for n-hexane was 51.32 +- 1.664%. Conclusion: Physalis minima root extract can be utilized to treat a variety of ailments and malignancies.

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