Saba Umar, Sohail Sabir, Nadeem Malik Azam, Muhaamad Aamir, Afshan Bibi, Ashfaq Altaf, Faud Ahmed Siddiqui, Haroon Sabir, Khalid Mehmood Raja, Batool Butt.
Comparison of Creatinine, Cystatin C and Combined Creatinine-Cystatin C for Renal Function Assessment in patients with Diabetes.
Pak Armed Forces Med J Jan ;72(3):771-74.

Objective: To compare the estimated glomerular filtration rate (eGFR) assessed through the CKD-EPI equations based on creatinine, Cystatin C and creatinine-Cystatin C levels for estimating kidney function among patients with diabetes. Study Design: Cross-sectional analytical study. Duration and Place of Study: Nephrology Department, Armed Forces Institute of Urology,, Rawalpindi, Pakistan, from Aug 2020 to Mar 2021. Methodology: A total of 70 patients were recruited. Serum samples were collected for creatinine and Cystatin C levels and 24 hours of urine for creatinine clearance. The eGFR values were calculated using the creatinine, Cystatin C and combined creatinine-Cystatin C CKD-EPI equations and compared with 24 hours of urinary creatinine clearance. Results: A total of 22 (31.4%) patients had early stage, while 48 (68.6%) had late-stage chronic kidney disease (CKD). The highest Spearman correlation coefficient was found for eGFR CKD-EPIcr-cys (rho=0.844), followed by CKD-EPIcys (rho= 0.835) and CKD-EPIcr (rho=0.709). Conclusion: CKD-EPIcr-cys is the most accurate, recommended method of calculating eGFR.

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