Salma Ghulam Nabi, Momin Iqbal, Aqsa Aslam, Sardar Faizan Khadim, Seemeen Ghafoor, Farzana Majeed.
Antimicrobial Activity of Zingiber officinale (Ginger) and Allium sativum (Garlic) Against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa.
J Sharif Med Dent Coll Jan ;08(1):26-30.

Objective: To evaluate the antimicrobial activity of ethanol extracts of ginger and garlic against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa and compare them with antibiotics used to treat infections caused by these bacteria. Methodology: It was a quasi-experimental study conducted at the Microbiology Department & Biochemistry Laboratory of Hazrat Bari Imam Sarkar Medical and Dental College, Islamabad from October 2021 to January 2022. After getting ethical approval from the Institutional Review Board, ethanol extracts of ginger and garlic were prepared and tested against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. The isolates were also tested against antimicrobials; ceftriaxone, oxacillin, and piperacillin/tazobactam for Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa, respectively. Data analysis was done using the Statistical Package for the Social Sciences (SPSS) version 25. Results: Among all ginger & garlic extracts and antimicrobials, the most significant zone of inhibition was produced by ginger day 3 extract against all bacterial isolates. The one-way ANOVA test showed a significant difference in the zone diameters of day 3 ginger extract compared to other extracts and antimicrobials (p-value <0.01). Conclusion: Ethanol extracts of ginger and garlic have significant antimicrobial activity and inhibit the growth of Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. The most effective is the day 3 ginger extract producing the most significant zone of inhibition against all bacterial isolates as compared to day 3 garlic extract, day 9 garlic & ginger extracts, and antimicrobials. Keywords: Antimicrobial activity. Garlic. Ginger.

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