Syed Ali Haider, Wardah Jabeen, Raza Haider, Amsa Zafar, Syeda Sarah Kazmi.
Outcomes of Whipple Procedure for Pancreatic Cancer: Initial Experience from a Public-Sector Hospital of Pakistan.
J Med Sci May ;30(03):202-6.

Objectives: The objective of this study was to review the outcomes of Whipple procedure at our institution.Material and methods: From 1st January 2017 to 31st December 2019, patients who underwent Whipple procedure for pancreatic cancer at Dr. Ruth K.M. Pfau Civil Hospital Karachi complying with the criteria were chosen for this retrospective cross-sectional study utilizing convenient sampling. Ages, gender, site of the disease, histopathology, operative findings, pancreatic reconstruction techniques, postoperative complications including SSI, intra-abdominal collections, chyle leaks, anastomotic leaks, and their management and 30-day mortality were recorded and analyzed. Results: The mean age of patients was 57+-13.62 years. The male-to-female ratio was 2.1:1. Jaundice was the most common symptom patients encountered. Surgical site infection (SSI) was the leading postoperative complication. Metastasis to dis-tant sites or locoregional recurrence evolved in 32.7% of patients. The 30-day mortality after surgery was 17.07%. 27 patients (65.9%) of the patients are alive and disease free and 14 patients (34.1%) expired due to recurrence.Conclusion: Pancreaticoduodenectomy is a complex procedure. However, with recent advancements, it has evolved into a safer procedure with significantly better surgical outcomes. Large-scale studies for identifying factors priming in poor out-comes along with stage-based and age-based comparisons are recommended.

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