Eed-uz Zaman M Saeed, Imran Taqi, Myousuf Jamal, Rozina Mustafa, Momna Ijaz.
Frequency of Type 2 Diabetes Mellitus and Comparison of the Mean ALT and AST Levels Between the Type 2 Diabetic and Non-Diabetic patients.
Esculapio J Services Inst Med Sci Jan ;15(2):127-30.

Objective: To determine the frequency of Type 2 diabetes mellitus and comparison of the mean ALT and AST levels between Type 2 diabetic patients and non-diabetic patients. Methods: The study was conducted in Department of Medicine, Services Hospital Lahore. Randomly 300 patients were enrolled from out patient department of medicine. Sample size of 300 cases was calculated with 95% confidence level and 3% margin of error taking expected frequency of diabetics to be 7.6% 2. Patients were selected with Non probability, consecutive sampling technique. Patients were investigated by performing Fasting blood glucose level, oral glucose tolerance test and Glycated HemoglobinA1c (HbA1c) level and diagnosed as diabetics as per American diabetic association criteria. Newly diagnosed diabetics were segregated as type 1 and type 2 on the basis of clinical criteria i.e. age of onset, body mass index (BMI), insulin requirement as initial therapy, previous history of diabetic ketoacidosis and associated autoimmune disorders. Results: Frequency distribution of patients with Type 2 diabetes mellitus showed that among 300 patients, 19%(n=57) had Type 2 diabetes mellitus . Mean ALT levels were deranged more in Type 2 diabetics (38.2+-13.4) as compared to non-diabetic patients (29.7+-12.6). Mean AST levels were also deranged more in Type 2 diabetics (39.7+-12.7) as compared to non-diabetics (32.6+-14.1). Conclusion: Mean AST and ALT values in patients with type 2 diabetes mellitus were deranged more than that of non-diabetic patients.

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