Muhammad Imran, Tuba Tariq, Sadia Haleema, Ameena Nasir, Saadia Sajjad, Qanita Mahmud.
Imagnetic Resonance Imaging as Diagnostic Tool for Acute Invasive Fungal Sinusitis.
Esculapio J Services Inst Med Sci Jan ;15(2):118-22.

Objective: To measure the diagnostic accuracy of magnetic resonance imaging for diagnosis of acute invasive fungal sinusitis taking histopathology as gold standard. Methodology: After obtaining permission from ethical committee of hospital, 150 patients meeting the study criteria were recruited in the study which was conducted in Department of Diagnostic Radiology, Sir Ganga Ram Hospital, Lahore. Informed consent was obtained. Demographic information (name, age, gender, contact) was also obtained. Then patients underwent MRI by using 1.5T magnets by a single senior radiologist. The imaging was performed with specified sinus views and sequences including T1-weighted images in axial plane, T2-weighted images with fat saturation in axial and coronal planes, and also contrast enhanced T1-weighted images with fat saturation in axial and coronal planes. Then patients underwent biopsy by a single surgical team under general anesthesia. Histopathology was then performed on the biopsy samples obtained during sinus surgery. Reports of MRI and histopathology were compared. Out of 150 patients who were clinically suspected of having fungal sinusitis 87 were negative for fungal disease on histopathology. Results: Sensitivity and Specificity of MRI for diagnosis of fungal sinusitis was 92.06% and 93.1% respectively. However positive predictive and negative predictive value for MRI for diagnosing fungal sinusitis was 90.63% and 94.19% respectively. Overall diagnostic accuracy of MRI was 92.67% respectively. Conclusion: Results of this study showed high sensitivity and specificity of MRI in making the diagnosis of fungal sinusitis. Considering the results of this study MRI can be used effectively for diagnosing of fungal sinusitis.

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