Sauda Usmani, Aysha Zaheer, Hamid Javaid Qureshi.
Hepatoprotective and Antioxidative Effectso of Allium Sativum Var Chinese Exoticon Acetaminophen Induced Acute Hepatitis in Male Albino Rats.
Esculapio J Services Inst Med Sci Jan ;15(2):106-10.

Objective: To determine the hepatoprotective and antioxidative effects of ethanolic extract of Allium sativumvar Chinese exotic on acetaminophen induced hepatotoxicity in male albino rats. Methods: This study was carried out on 90 male albino rats. A single intraperitoneal dose of acetaminophen 750mg/kg was used to induce oxidative stress and hepatotoxicity. The rats were randomly divided into three groups of thirty each. Group A was given normal saline (negative control); group B was administered hepatotoxic dose of acetaminophen(positive control); group C (experimental) was pretreated with Allium sativum Var Chinese exotic extract for 7 days before receiving hepatotoxic dose of acetaminophen (Experimental). Serum ALT, AST, ALP, total proteins, albumin and glutathione peroxidase levels in each group were estimated from terminal blood sampling done 24 hours after acetaminophen administration under ether anesthesia. Results: Allium sativumvar Chinese exotic manifested hepato-protective and antioxidative effects by producing highly significant (p=0.000) reduction in serum ALT and AST, but no significant (p=0.335) reduction in serum ALP levels. This garlic extract also produced highly significant (p=0.000) increase in serum albumin and significant increase in serum total proteins (p=0.027) and glutathione peroxidase (p=0.025) levels. Conclusion: Allium sativumvar Chinese exotic has potent hepatoprotective and antioxidative potential.

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