Ahmad Raza Khan, Memona Yasmin, Khalid Mahmood, Muhammad Abaidullah, Naveera Ahmed.
Determination of age of Puberty Using Leptin Level in Male Population.
Esculapio J Services Inst Med Sci Jan ;15(2):94-8.

Objective: Innovating puberty analysis via utilization of leptin as a biomarker to revolutionize existent archetype prototype paragon. Methods: It was a cross sectional study based on pubescence markers utilized as landmark criterion. Healthy volunteer males of disparate maturescence were selected. Their physical maturity was substantiated via gold standard tanner staging and correlative algorithm was established with serum leptin levels. Sample size calculative of 150 was collected. Results: Leptin levels dependent on age groups were stratified. These leptin level ranged from a minimum pre-pubertal level of 0.174 ng/ml to maximum 7.704 ng/ml at puberty initiation, which exhibited a peak upraise of the leptin mean value of 3.57 ng/ml +- Std. Dev. 1.608 ng/ml, during the puberty startup averaging up to 12.5 years, with a progressive decline from mid-puberty to post-puberty age represented by the fall in leptin level from 2.539ng/ml to 0.174ng/ml respectively, with a mean value of 1.021ng/ml +- 0.611ng/ml Conclusion: Leptin incentivized study was in pursuance of establishing a correlation between leptin in regards with juvenility along with evaluating range of leptin levels at which the maturity is initiated. The prospective study was deployed via utilizing pinnacle paradigm of tanner staging supplemented by leptin analysis. Data obtained was analyzed statistically for computation of puberty attainment age. Epitome of research conclusively analyzed a correlation between serum leptin and puberty initiation and an incontrovertible definitive leptin level range to assess the maturescence staging from initiation to complete adulthood.

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