Muhammad Rashid, Ali Raza, Muhammad Shahzad Chaudhry, Asma Munir, Muhammad Shahzad Hafeez, Amtiaz Ahmad.
Comparison of heparin-induced thrombocytopenia in patients treated with un-fractionated vs. low-molecular weight heparin.
Esculapio J Services Inst Med Sci Jan ;15(3):210-3.

Objective: To compare the frequency of heparin-induced thrombocytopenia with un-fractionated vs. low-molecular-weight heparin in patients presenting with deep vein thrombosis Methods: This randomized control trial was conducted at department of medicine, Mayo Hospital, Lahore for 6 month i.e. 18-05-2016 to 19-11-2016. Informed consent was taken from all the patients. The non-probability, consecutive sampling technique was used. All the data was collected in terms of two groups. Group A consists of patients receiving UFH 2.5cc in 97.5cc normal saline in micro-burette @8udrops/min continuous infusion while group B consists of patients receiving LMWH (injection enoxaparin) 60mg subcutaneously twice a day. Platelet count was done on 3rd and 10th day. If platelet count is found to be <50% than baseline, then HIT was labeled. All the collected data was entered and analyzed on SPSS version 20. Results: In our study the mean age of the patients was 52.33+-7.38 years, the male to female ratio of the patients was 1.14:1. In this study the HIT was found in 9(3.75%) patients. Statistically significant difference was found between the study groups with HIT of the patients. i. e p-value=0.017 Conclusion: HIT is an established complication of heparin therapy. Use of LMWH significantly decreases chances of HIT as compared to UFH in patients presenting with DVT in medical wards.

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