Saman Ali, Muhammad Ali Haider, Nida Usman, Hafiza Ummara Rasheed.
Association Between Central Corneal Thickness and Intra Ocular Pressure in Management of Primary Open Angle Glaucoma.
Al-Shifa J Ophthalmol Jan ;17(3):109-16.

Purpose: To assess the differences between intraocular pressure measured by Goldman Applanation Tonometer and adjusted value of intraocular pressure (IOP) based on central corneal thickness (CCT) and emphasize the significance of use of this adjusted value IOP based on central corneal thickness for management of Glaucoma. Methodology: Patients of primary open angle glaucoma meeting the criterion coming to glaucoma clinic Mayo Hospital Lahore were included in the study. After taking informed consent patients were examined on slit lamp, IOP by GAT was taken with & without CCT(done by pachymeter). Probe of pachymeter after sterilization touched the center of the cornea and average of five connective readings in micrometer with standard deviation of three were taken. The adjusted IOP and target IOP was calculated. Visual field (VF) and Optical Coherence Tomography (OCT) were performed and previous treatment noted and change in treatment made according to adjusted IOP. Comparison was seen between the both treatment strategies that is treatment on bases of IOP without CCT and with CCT. Results: Out of 105 patients, 40.9% males and 59% females were included in this study. The male corneas were found to be thinner in the range 445-617 micrometer with the mean 523 micrometers than females in the range of 475-650 micrometers with the mean of 552 micrometers. In our study it was found that there is a positive relationship between adjusted IOP based on CCT and treatment according to it where r = 0.723 and p = 0.000, which is less than p = 0.05 and shows significant results. Pearson correlation results shows positive direct relationship by adjusting IOP based on CCT and treatment affect according to adjusted IOP. Conclusion: Exact/adjusted IOP help in accurate assessment and management of glaucoma and imparts less financial burden on the society.

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