Kinza Ayub, Mohsin Fazal.
The Effectiveness of Submucosal Administration of Methylprednisolone and Dexamethasone in Comparison to Placebo after Third Molar Surgery: a Double Blinded, Parallel Arm Randomized Clinical Trial.
Pak J Med Res Jan ;61(4):154-9.

Background: Third molar or wisdom tooth removal is the most recorded surgery in all maxillofacial clinics globally. Post-operative complications can range from crucial complications such as damage to inferior alveolar nerve, infection, fracture of mandible, dry socket to frequent complains like pain, edema and swelling which can disturb the daily routine of patients. Several methods including use of different types and routes of corticosteroids have been used to reduce the discomfort and improve the quality of life postoperatively. Objective: To compare effect of submucosal administration of dexamethasone 8mg and methylprednisolone 40 mg with placebo ( saline) one hour prior to third molar surgery in reducing the post operation sequelae after the third molar removal surgery. Study type, settings & duration: This double blinded, parallel arm randomized clinical trial was carried out in Oral and Maxillofacial Ward of Islamic International Dental College, Islamabad from January to June 2019.   Methodology: The trial was registered in Australian and New Zealand international trial registry. The sample size was calculated by WHO calculator. A VAS variance was stated as 3 for drugs and 14 for intergroup. Errors were set as alpha =0.05 and beta=0.2. A total sample size was calculated to be 90 patients. A total of ninety patients were included and were divided into three groups. Each group had thirty patients .........   

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