Rizwan Ali Talpur, Yar Muhammad Nizamani, Hanozia Hassan, Aamir Hussain, Ameer Abbas Ali, Rabnawaz Sathio.
A comparison of Lipid Profile and Highly Sensitive C Reactive Protein (HsCRP) levels between prehypertensive individuals and those with normal blood pressure..
Professional Med J Jan ;30(8):1048-54.

Objective: In the current study, hsCRP and lipid profile levels in pre-hypertensives were assessed and compared with those in normal subjects, as well as blood pressure and lipid profile correlations were examined. Study Design: Cross-sectional. Setting: Department of Physiology, Liaquat University of Medical & Health Sciences (LUMHS) in Jamshoro. Period: Six months 1st November 2022 to 30th April 2023. Material & Methods: From the general population, 50 pre-hypertensive and 50 normotensive subjects ranging in age from 25 to 55 were enrolled. A blood pressure measurement and an anthropometric measurement were taken. Student t tests were used to compare serum hsCRP with lipid profiles. In order to correlate blood pressure with hsCRP and lipid profile, Pearson correlation was used. Results: A significant correlation was not found between blood pressure (SBP and DBP) and hsCRP in either group. When compared to normal individuals, pre-hypertensives had significantly higher cholesterol and LDL (P-value <0.001). Among prehypertensive patients, blood pressure and lipid parameters did not seem to be significantly correlated. Conclusions: We conclude that in both prehypertensive and normal subjects, hsCRP levels are not significantly different. Therefore, pre-hypertensive patients do not have inflammation. Prehypertensive patients have significantly higher total cholesterol and LDL levels than normal individuals. There is an alteration in the lipid profile of prehypertensive individuals.

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