Mehir Un Nisa Iqbal, Syed Amir Maqbool, Taseer Ahmad Khan.
Breast Cancer: Impact of Modifiable and Non-Modifiable Risk Factors among Premenopausal Women of Karachi, Sindh.
J Aziz Fatm Med Den College Jan ;5(1):18-24.

Objective: The goal of present study was to probe the interplay between modifiable and non-modifiable factors and breast cancer (BC) risk. Methodology: Two hundred and twenty-eight (228) BC cases and 503 healthy volunteers with 20-45years of age without history of BC were recruited from tertiary hospitals located in Karachi, a metropolitan city of Pakistan. Major risk factors for the BC were evaluated using pretested self-structured questionnaire. Results: The adjusted regression analysis showed that Balouchi (OR=12.93, 95%CI=4.26-39.17) and Sindhi (OR=9.41, 95%CI=4.72-18.77) ethnicity, familial history of BC (OR=1.83, 95%CI=1.16-2.91), low socio-economic status (OR=26.81, 95%CI=17.56-40.94), marital age >30yrs (OR=20.99, 95%CI=4.15-106.24),hormone replacement therapy (OR=1.95, 95%CI=1.03-3.69), being obese (OR=1.589, 95%CI=1.03-2.46),high waist-to-Hip ratio (WHR) (OR=2.69, 95%CI=1.67-4.32), apple shape body (OR=2.62, 95%CI=1.63-4.21), consanguineous marriages (OR=1.62, 95% CI=1.15-2.29) and sun exposure <1 hr/day (OR=7.56,95%CI=3.002-19.04), daily intake of beef (OR = 1.544, 95%CI=1.004-2.373), dry fruits (OR=1.922,95%CI=1.233-2.996), rice (OR= 2.412, 95%CI=1.17-4.973), tea and coffee (OR=2.299, 95%CI=1.246-4.24)and less consumption of milk (OR=1.942, 95%CI=1.344-2.807) and fruits (OR=2.952, 95%CI=1.505-5.792) were increased the BC risk among premenopausal women. Conversely, first pregnancy <24yrs (OR=0.53,95%CI=0.33-0.85), WHR <0.85 (OR=0.296, 95%CI=0.15-0.59), avocado body shape (OR=0.31,95%CI=0.16-0.61), excessive chicken (OR=0.403, 95%CI=0.206-0.791) and eggs (OR=0.479, 95CI=0.304-0.755) consumption were considered a protective factor. Conclusion: Ethnicity, SES, marital age, HRT, breast cancer family history, overweight and obesity, intermarriages and sun exposure may be the major risk factors for BC among premenopausal women of Sindh, Pakistan. Diet may also play a role in developing BC.

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