Masood Ul Haq, Masood Ul Haq, Shamshad Rasul, Saulat Ullah Khan, Saqib Saeed, Tariq Mehmood Tahir.
Anti Tuberculosis drug induced Hepatitis.
Pak J Chest Med Jan ;7(Suppl):41-5.

Materials and Methods: One hundred and sixty seven (167) consecutive patients admitted in Institute of Chest Medicine, Mayo Hospital, Lahore during the months of June, July and August 1998. with diagnosis of pulmonary and /or extra pulmonary Tuberculosis were the subjects of this study. Socio-demographic characteristics, treatment history, extent of disease on chest X-ray and presence of any other co existing disease recorded. Liver function tests including serum bilirubin, S. alkaline Phosphatase, SGOT and SGPT at the start of treatment. They all were prescribed Rifampicin, Isoniazid Ethambutol and Pyrazinamide (RHEZ) according to body weight. AI I the patients were observed for clinical evidence of jaundice during the course of treatment and liver function tests repeated when indicated. Incidence of hepatitis is being studied in the subjects of this study in relation with the age, sex, extent of disease, duration of anti-tuberculous treatment and chemotherapeutic status. Results: There is larger proportion of younger patients with slight preponderance of male gender. Incidence of hepatitis is higher in those older than 35 years and females are more commonly affected. Out of total 167 tuberculosis patients, 144 had pulmonary tuberculosis while 23 had extra pulmonary involvement. Results show that 5 out of 11 patients who had hepatitis were having far advance (FA) disease. On appearance of jaundice, rifampicin, INH and pyrazinamide were stopped and patients were continued on ethambutol, streptomycin and ofloxacin. Out of 11 patients, three died during treatment, jaundice cleared in remaining 8 patients in 7-15 days.

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