Ahmed Z, Yaqoob N, Muzaffar S, Kayani N, Minhas R.
Solid cystic Papillary Epithelial neoplasm of Pancreas: a series of three cases with review of literature.
J Pak Med Assoc Jan ;54(7):392-4.

A 16 year old girl from Peshawar presented with a history of abdominal mass. No other clinical details were available. Laparotomy had been performed and biopsy diagnosis from Peshawar was Wilm`s tumor. The case was sent to us for second opinion. We received five paraffin blocks and partly five Hand E stained slides. All the sections showed a neoplastic lesion with partly solid and partly pseudo papillary pattern, the tumor cells were monomorphic with round to ovoid nuclei and inconspicuous nucleoli. Mitoses were rare. In areas, the tumor cells were radially arranged around minute fibro vascular stalks. In one of the sections, benign pancreatic tissue was seen with no infiltration by the tumor. Immunohistochemically, the tumor cells showed positivity for vimentin and NSE (neuron specific enolase), while chromogranin A, synaptophysin, cytokeratin MNF and Cytokeratin CAM 5.2 were negative. Based on histopathological and immunohistochemical features, a diagnosis of solid-cystic papillary epithelial neoplasm was favored and clinical and radiological correlation was advised.

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