Yasmin Mussaddeq.
Effect of Thyroid hormone on postnatal alkaline phosphatase activity.
J Pak Inst Med Sci Jan ;13(2):675-81.

Hypothyroidism and hyperthyroidism were induced during postnatal growth of rats and AP (Alkaline phosphatase) was measured in the calvarium homogenate rather than in the blood plasma to directly assess changes in the mineralization process. PTU (Propylthiouracil) treated rats showed depressed levels of AP activity in the calvarium expressed either per unit protein or per pg DNA which indicates delayed bone growth in response to PTU. In contract, T4 (Thyroxine) treated animals showed high levels of AP activity when compared with PTU treated rats but showed depressed AP activity when compared to both controls. However, T4 treated levels are significantly higher than control for pg DNA/g of bone and mg protein/g of bone. The relative specific` activity of AP may be decreased in relation to presence of other proteins which are increased in response to the hormone.

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