Zafarullah Khan, Sarah Shoaib, Tahir Masood Ahmed, Sajid Maqbool, Zeenat Isani, Khalid Mehmood, Awn Bin Zafar, Nizamuddin Gilal.
Efficacy and safety of Halofantrine hydrochloride in malaria treatment.
J Pak Inst Med Sci Jan ;15(1):853-6.

Malaria is an infectious disease caused by protozoon, Plasmodium. We tested the efficacy and safety of halofentrine in adults and children suffering form malaria in Pakistan. A total of 102 patients diagnosed as having malaria by blood smear received 3 doses of 500mg Halofantrine at 6 hrly interval. Clinical and blood indicators of malaria cure were measured and patients followed for 21 days or 28 days in case of relapse. Out of a total of 102 patients enrolled, 93 subjects completed the study. Only 09 subjects were dropped out of study, none of them due to adverse events. 96.08% of subjects were cured at the end of study period. 2.94% failed to cure and 0.98% relapsed after 120 hrs after first dose. Median parasite clearance time was 26 hrs and median fever clearance was 29 hrs. 11.74% of subjects reported at least 1 adverse event during study period. None reported serious adverse events during study period. From efficacy and safety analysis data, it is evident that Halofantrine achieved efficacy in 97%, relapse rate < 1% and short parasitic clearance time i.e. 26 hrs from the first dose. A good safety profile was established as there were no serious adverse events.

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