Khalil Ur Rehman, Rizwan Hashim, Asmaa Qureshi, Muhammad Tayyab.
Subtotal Thyroidectomy: changes in the thyroid autoantibody level following Surgery & Radioiodine therapy.
Professional Med J Jan ;11(1):16-21.

Objective: Autoimmunity is common in thyroid diseases. Antibody level is affected after subtotal thyroidectomy and radio iodine treatment. We studied microsomal & thyroglobulin autoantibody level in patients with toxic diffuse goitre and multinodular goitre before and after surgery & radio iodine to determine effects of therapy. Design: Prospective study. Settings: Postgraduate Medical Institute, Lahore. Material & Methods: Three serial blood samples from each of a total of 30 seropositive patients (15 of multinodular goitre, undergoing thyroid surgery. 15 of toxic diffuse goitre receiving radioiodine) were analyzed for microsomal & thyroglobulin autoantibody using tagged red cell haemagglutination technique. Results: We found a female preponderance in thyroid diseases. The microsomal & thyroglobulin autoantibody level in patients with multinodular goitre, decreased gradually and progressively after subtotal thyroidectomy while subjects with toxic diffuse goitre receiving radioiodine showed a rise in antibody level as compared to pretreatment period. The change became evident just after 10 days of therapy. Conclusion: The autoimmune status of thyroid disease patients is altered after subtotal thyroidectomy & radioiodine therapy. The autoantibody levels after subtotal thyroidectomy are gradually decreased while after radioiodine therapy the antibody levels have been found to increase.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com