Zahoor Ul Hassan Dogar, Munir A Shiekh, Asghar Bajwa, Shoaib Akhtar, Farooque M, Muhammad Nawaz, Farkhanda Almas.
Lymphoblastic Leukemia; variations in biochemical parameters toxicity with the type of induction treatment.
Professional Med J Jan ;11(1):38-43.

The present study was the continuation of the project in which two different treatment protocols were applied to evaluate the efficiency of each treatment. 42 total cases were taken divided equally into two groups. Group I was treated by conventional treatment DVP (Daunorubicin + Vincristine + Predinisolone). In 2nd Group DVP & L-asparginase enzyme was applied. The effect of two treatments on various biochemical parameters were studies by taking samples after each 0.5% months during induction therapy (3 months) and after induction therapy till 6 months. The results showed greater rise in blood ALT, ALP and amylase levels in Group II, as compared to the findings found in Group I. Similarly a relative rise in blood glucose, urea and bilirubin was also found in Group II as compared to Group I. It clearly indicates that after addition L-asparaginase although beneficial for induction therapy but resulted in deleterious effects development on different vital organs in the body. Its use should be strictly under control of a clinical biochemist so that its toxicity should not over balance its benefits.

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