Farzana Latif, Zahwa Waseem, Naila Yasmin, Rai Muhammad Hammad Arif, Shabnum Tahir, Noreen Latief.
Comparison of adequate endometrial tissue sample received by histopathologist by manual vacuum aspiration versus dilation & curettage in women presenting with abnormal uterine bleeding.
Pak Postgrad Med J Jan ;34(1):38-42.

Background: Abnormal uterine bleeding (AUB) is bleeding coming from uterine corpus, altered in volume, regularity, or time. Tests like D & C (dilatation and curettage), pipelle biopsy, brush biopsy and MVA (manual vacuum aspiration) that take biopsy from the endometrium can be done to diagnose endometrial cancer and its other pathalogies. Objectives: To compare the endometrial tissue in terms of adequate sample received by pathologist of manual vacuum aspiration versus dilation & curettage in females presenting with abnormal uterine bleeding. Methods: It was a Randomized Controlled Trial performed in Department of Obstetrics & Gynecology, Lahore General Hospital, Lahore for one year (April 3, 2020 till April2,2021). 390 females were equally divided in two groups by lottery method. Ingroup A, females had endometrial sampling with MVA. Ingroup B, it was by dilatation and curettage by single surgical team. Efficacy was labelled when a pathologist could identify the endometrial epithelium, stroma, and glands of endometrium to make proper diagnosis of sample. Results: The mean age of females in MVA group was 55.07 +- 6.10 years and 55.5+- 6.07 years in the D & C group. The mean duration of AUB in MVA group was 17.26 +- 4.12 months and in D &C group, it was 17.44 +- 2.51 months. In MVA group, 170(87.2%) cases had adequate endometrial sample and in D & C group, it was in 181(92.8%) cases, the frequency of adequate endometrial sample in both groups was statistically insignificant i.e., p-value > 0.05. Conclusion: Although the percentage of collection of adequate endometrial tissue in D & C group was high than MVA but it was not statistically significant. So MVA being simple and quick procedure, can be used as an outdoor procedure, with less blood loss, without general anesthesia.

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