Talha Ijaz, Sidra Syed, Hafiza Sana Ashraf, Mizha Fatima, Hajra Shehzadi, Mughees Ahmad.
Association of Restless Leg Syndrome with Sleep Quality and Fatigue in Chronic Kidney Disease patients with and without Hemodialysis: a Cross-sectional Study.
Healer J Physiotherap Rehab Jan ;3(4):461-8.

Background: Restless leg syndrome also known as Willis-Ekbom disease, is a neurosensory-motor illness that is characterized by a decrease in quality of life as well as unpleasant sensations that frequently manifest themselves when a person is sleeping or in late afternoon or evening. Objective: To determine the association of restless leg syndrome with sleep quality and fatigue in chronic kidney disease patients with and without hemodialysis. Methods: In this cross-sectional study data was collected from different hospitals of Lahore, Pakistan in six months after receiving approval of the synopsis from 151 individuals using non-probability convenient sampling. To be included in the study, participants aged between 18 to 75 years, undergoing dialysis at least two times a week and diagnosed with chronic kidney disease on medication or dialysis for at least 6 months. Participants with neurological or psychiatric diseases, compartment syndrome, varicose veins, lower limb surgery, active cancer, severe cognitive impairment or aphasia leading to difficulty in communication or being confined to bed or wheelchair. The mean and standard deviation were used to describe the variables. The chi-square test was conducted to determine if there was an association between restless leg syndrome, sleep quality and fatigue symptoms in hemodialysis patients and those who did not undergo it. Results: The study included 78 males (51.7%) and 73 females (48.3%). This table showed the mean and standard deviation of several different variables such as age, height, weight, body mass index, age at first dialysis (year), duration of dialysis, Pittsburgh sleep quality index and fatigue severity scale. It was indicated that patients on dialysis have higher scores as compared to those on medications as the p-value was found statistically significant. Conclusion: The association of restless leg syndrome with sleep quality and fatigue in chronic kidney disease patients with and without hemodialysis is significant. Furthermore, patients with this disease who are on hemodialysis have been found to have a higher prevalence as compared to those not on hemodialysis. This can affect sleep quality and fatigue in such patients and can exacerbate the symptoms.

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