Kanwal Ashiq, Sana Ashiq, Naureen Shehzadi.
Hyperuricemia and its association with hypertension: risk factors and management.
Pak Heart J Jan ;55(2):200-1.

Hyperuricemia is a medical condition that arises due to the increased concentration of uric acid in the body. Worldwide, a surge in the number of hyperuricemia cases has been seen over the last ten years. Hyperuricemia develops when the concentration of uric acid persistently crossed its normal threshold value (6 mg/dL). Uric acid is a metabolic product of purine catabolism. During the metabolism of purine, hypoxanthine is formed which is later on converted to xanthine and uric acid by the action of the xanthine oxidase enzyme. A continual increase in levels of uric acid is a major biomarker of developing gouty arthritis. Clinically, gouty arthritis is characterized by inflammation and pain in joints due to the accumulation of urate crystals in and around the affected area.1 Recently, hyperuricemia-induced renal and cardiovascular diseases have gained more consideration. Hyperuricemia is not only associated with gout but also linked with other comorbidities, including diabetes type II, heart diseases, and hypertension.

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