Muhammad Asghar, Muhammad Rehan Burney, Muhammad Akmal.
Effects of intravesical BCG therapy on superficial bladder cancer (recurrence and progression).
Pak Armed Forces Med J Jan ;54(1):4-6.

The present study was conducted to determine the efficiency of the intravesical BCG therapy on superficial bladder tumor recurrence and progression. 39 patients at AFIU Rawalpindi from Jan 1999 to Jan 2002. All patients with superficial bladder tumor were included in the study. Patients with Carcinoma Urinary Bladder were evaluated with Ultrasound Kidney and Urinary Bladder, examination under anaesthesia, cystoscopy, and histopathological examination. Sixteen patients with superficial bladder tumor were given BCG therapy two weeks after transurethral resection. This consisted of induction with six instillations at weekly intervals, followed by three monthly check cystoscopies. Control group (twenty three patients) underwent transurethral resection followed by check cystoscopy at three monthly intervals. Both recurrence rate and tumor progression was low (12.05% and 6.25% respectively) in BCG treated group, compared with higher tumor recurrence and tumor progression (65.25% and 26.10% respectively) in the control group. BCG instillation therapy in superficial bladder tumors significantly reduced the rate of tumor recurrence and tumor progression.

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