Sajjad Khan, Arshad Mehmood, Raheel Khan, Huma Asad.
Role of Intravenous Cefuroxime Antibiotic Prophylaxis in the Prevention of Surgical Site Infection in Open Mesh Inguinal Hernia Repair.
Pak Armed Forces Med J Jan ;73(6):1835-7.

Objective: To compare pre-operative intravenous Cefuroxime prophylaxis to no prophylaxis regarding the development of surgical site infection in inguinal hernia mesh repair. Study Design: Quasi-experimental study. Place and Duration of Study: Department of Surgery, Combined Military Hospital, Bahawalnager Pakistan, from Nov 2015 to Nov 2017. Methodology: A total of 230 patients were included (115 patients in each group). Group-A patients were subjected to preoperative administration of 1.5 gm intravenous Cefuroxime 1 hour before surgery, while Group B patients were subjected to no antibiotic prophylaxis following mesh repair. Development of post-operative surgical site infection (SSI) was checked till the 30th post-operative day (POD). Results: Post-operative surgical site infection was comparatively less in Group-A (3.4%) as compared to Group-B (10.4%), which was statistically significant (p-value0.038). Conclusion: Pre-operative intravenous Cefuroxime prophylaxis significantly reduces post-operative SSI following mesh inguinal hernia repair.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com