Mukhtar Ahmad, Khemomal Kharira, Jamshad Iqbal.
Ionic imbalance; a risk factor for pathogenesis of cardiovasular disease.
Professional Med J Jan ;8(2):199-202.

Hypomagnesemia affects the cardiovascular homeostasis through influences on the internal balance of Na+, K+ and Ca++. It causes significant perturbations in plasma lipids that would favor arteriosclerosis. OBJECTIVES: This clinical study was carried out to find correlation between serum magnesium level and clinically diagnosed cardiovascular dysfunctions. MATERIAL & METHODS: 90 patients having cardiovascular dysfunctions (clinically) were compared with a similar number of controls regarding their serum magnesium levels. RESULTS: Serum Mg++ was found to be significantly decreased (P < 0.001) and this correlates inversely with increased serum Na+, K+ and Ca++ levels. Serum levels of total cholesterol, triglycerides and LDL- cholesterol were significantly increased (P<0.001) whereas HDL-cholesterol levels were significantly decreased (P<0.001) in these patients. CONCLUSION: Magnesium deficiency may affect lipid metabolism and it should be supplemented to avoid cardiovascular dysfunctions.

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