Ahmed Hameed, Arif Hussain, Tahira Fayyaz, Muhammad Tayyab, Janbaz Ahmad.
Chronic liver disease; Assessment of Antithrombin III levels.
Professional Med J Jan ;9(2):100-5.

In his study was designed to estimate AT III levels in patients with chronic liver disease and to correlate it with other coagulation screening tests. In the present study 30 patients of chronic liver disease (cirrhosis) were included. Twenty healthy controls were selected who have no liver disease, not taking any hepatotoxic drug or any anticoagulant. The following tests were performed, AT III levels PT, APTT, Fibrinogen levels and serum albumin. Significantly reduced levels of AT III were recorded in the patient group as compared with the healthy controls. A significant negative correlation was found between AT III and Prothrombin time. The patient showed reduced AT III levels with normal PT. A positive correlation was found between serum albumin and AT III. It is concluded that reduced AT III level is more sensitive indicator of synthetic function of liver and thromboembolic phenominon should be suspected in patients of chronic liver disease when AT III levels are reduced

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com