Mirza Akmal Sharif, Pirzada Muhammad Anwer, Aamir Shoukat, Naeem Ahmad.
Amlodipine as anti-anginal; A clinical trial.
Professional Med J Jan ;9(2):130-5.

OBJECTIVE: To study the effects of Amlodipine in angina pectoris patients. DESIGN: Prospective study. SETTING: Medical Unit II Allied Hospital, Punjab Medical College Faisalabad PERIOD: Total duration was 7 weeks. SUBJECT & METHODS: Twenty patients with symptomatic chest pain were included and were assessed for seven weeks. This assessment was made by the number of glyceryl trinitrate (GTN) tablets required per week. RESULTS: Out of 20 patients, 12 were male and 8 were female having mean age of 54.7 years. A mean height was 165.3 cm and mean weight was 71.4 kg in both sexes. The patients were followed for 7 weeks and were maintained at 10 mg amlodipine once a day. Significant reduction of anginal attacks was seen i.e. 70% from base line. Use of nitrates was also reduced as well as reduction in heart rate from 84-78 beats per minute. Amlodipine was well tolerated and effective. CONCLUSION: This 2d generation dihydropyridine calcium antagonist was found to have both anti hypertensive and anti-anginal property with good safety profile and tolerance.

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