Qurban Ali Khaskheli, Saleem A Kharal, Anjum Syed, Qazi Muhammad Rizwan, Muhammad Asif Durrani.
Serodiagnosis of Helicobacter Pylori infection.
Professional Med J Jan ;9(2):145-53.

Myocardial infarction, an increasing plaque of modern society, is a disorder of multifactorial nature. Many cases of MI have been reported with causes of established cardiovascular factors. This unexplained situation suggests that there are important unrecognized factors to play a role in the development of myocardial infarction. In this regard infective agents such as H.pylori is reported to increase the risk of myocardial infarction. Therefore this study was designed to observe the anti H.pylori antibodies (IgG) and role of H.pylori in myocardial infarction patients, and comparative study of ELISA technique and ICT (Kit) method, to see their sensitivity, specificity, positive and negative predictive values in diagnosing the H.pylori infection. The results showed significantly higher levels of IgG antibodies against H.pylori in myocardial infarction patients, 103 (68.7%) as compared to controls 22 (44%) showing significant difference (P<0.003). The positive and negative predictive values were 89.1% and 87.5% respectively. So the study demonstrated no link between H.pylori infection and myocardial infarction. The results of ELISA and ICT, when compared, are similar showing no significant difference both for patients and controls (P<0.445) and (P<0.424) respectively. Therefore we concluded that although, ELISA technique is considered goldstandard but it is time consuming, costly, and quite labour intensive while the ICT method is easy, cheap, give results with in ten minutes which makes it A fastest test in diagnosing H.pylori infection.

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