Sohail Mahmood.
Hyperprolactinemic Infertility; Clinical trial for the management and comparison between two treatment regimes.
Professional Med J Jan ;9(3):201-6.

OBJECTIVE: To compare the success of two therapies, bromocriptine (parlodel) alone and bromocriptine in combination with clomiphene citrate in the treatment of infertile women with the diagnosis of hyperprolactinaemia to restore menstruation, onset of ovulation and to achieve pregnancy. DESIGN: Prospective study. SETTING: Bahawal Victoria Hospital Bahawalpur PERIOD: From 1st June 1994 to 30`h May 1995(one year study). SUBJECTS: Total of 58 patients were collected, of which, 18 lost contact in the initial visit, leaving 40 patients for analysis. In this study the patients included were with the biochemical diagnosis of hyperprolactinaemia associated with irregular, overdue periods and anovulatory cycles. Amenorrheic women with no evidence of ovarian estrogen production and elevated FSH levels were excluded. RESULTS: Total 40 patients were divided into two groups. One group of 20 patients was given bromocriptine alone. Out of these, 19 patients restored menstruation (95%), 16 patients started ovulation (80%) and 13 patients conceived (65%). In the second group of 20 patients who were put on bromocriptine plus clomiphene citrate, the results turned out as restoration of menstruation in all 20 patients (100%), 18 started ovulation (90%)and 15 patients conceived(75%). CONCLUSION: Hyperprolactinaemic infertile patients with menstrual irregularities and anovulatory cycles (in whom other causes of infertility were carefully excluded) show better response when clomiphene citrate is administered in combination with bromocriptine as compared to treatment with bromocriptine alone.

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