Muhammad Mazhar Hussain, Ahmed Kamal Ansari.
Ventilatory Lung Functions and total serum IgE in Bronchial Asthma.
Pak Armed Forces Med J Jan ;46(2):3-10.

Ventilatory lung functions offer a useful tool in the diagnosis of pulmonary diseases, assessment of their severity and response to therapy. Whereas, total serum IgE levels can be used to differentiate the allergic individuals from the non-allergic patients. Present study was planned to ascertain the levels of total serum IgE and ventilatory lung functions in the healthy control and asthmatic subjects attending the Out-Patient Department of Thoracic Medicine at J.P.M.C. Fifty healthy controls and an equal number of asthmatics were investigated for the ventilatory lung functions using Autospiro (model AS-500) spirometer. The estimation of total serum IgE was carried out by the enzyme immunoassay. The current data revealed the higher levels of total serum IgE; 195.26 26.21 IU/ml (Mean + SEM) in the native healthy adults as compared to the data available in the European population. The level of total serum IgE in 72% of asthmatic patients was found to be 1383.83. 338.00 IU/ml (Mean +/- sem) which was significantly higher as compared to those obtained from the controls in the similar age and sex group. Such asthmatics exhibited a significant decline (P < 0.01) in ventilatory lung functions (FVC, FEV1, FEF 25-75% and PEF). The present data suggest that IgE is related to the environmental, geographical and allergic conditions. Furthermore, the impairment of ventilatory functions is associated with the raised levels of total serum IgE in large number of asthmatics which indicates the fundamental role of the immunoglobulin.

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