Usman Ahmad, Saeed Mahmood, Safiuddin Siddiqui, Philippe M Frossard.
Effects of apolipoprotein E polymorphism on the development of stroke.
J Pak Med Assoc Jan ;54(12):626-32.

As cholesterol is insoluble in aqueous solutions, its transport takes place in the form of particles, which are rendered soluble by the presence of apolipoproteins on their surface. The apolipoproteins and polar lipids form a nonmolecular film that surrounds the non-polar lipids in the core of the particle. The apolipoproteins (APO) involved are APOB48, APOB 100, APOCII and APOE. If the metabolism and production of any of these lipoproteins is disturbed, it will lead to derangements in cholesterol metabolism leading to either hypercholesterolemia or hypocholesterolemia, which are important risk factors for many disorders including IHD, hypertension and hepatic disorders.

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