Tanveer Jilani, Tehseen Iqbal, Salahuddin, Akbar Khoja.
Role of endogenous vitamin E in exercise induced lipid peroxidation in trained and untrained healthy people.
Med Channel Jan ;10(3):51-4.

OBJECTIVES: To study and compare the changes in serum vitamin E and malondialdehyde levels between physically trained and untrained healthy people after an acute bout of physical exercise. SETTING: Department of Physiology, Basic Medical Sciences Institute (BMSI), Jinnah Postgraduate Medical Centre (JPMC), Karachi from June 1999 to May 2000. SUBJECTS AND METHODS: A total of 60 apparently healthy (30 males and 30 females) randomly selected subjects with a known history of regular physical exercise (i.e. trained control groups A and B respectively) and another total of 60 apparently healthy (30 males and 30 females) randomly selected subjects without history of any regular physical exercise (i.e. untrained Test groups C and D respectively) with ages ranging between 18 to 40 years, under an acute bout of similar moderate intensity exercise of 30 minutes duration on a bicycle ergometer (after their age and Body mass index matching). Their pre and post exercise serum vitamin E and malondialdehyde levels were estimated and compared for statistical analysis. RESULTS: Serum malondialdehyde levels were significantly (P < 0.05) increased in both control and test group subjects at the end of an acute bout of physical exercise as compared to their basal levels. There was a significant (P < 0.05) decrease in 1-hour post exercise serum malondialdehyde levels in control group (A and B) subjects as compared to their immediate post exercise levels. However no such decrease was found in test group (C and D) subjects whose 1-hour post exercise in serum malondialdehyde levels remained almost the same as compared with their immediate post exercise levels. Results also indicate that serum vitamin E levels were significantly (p<0.05) increased in both trained and untrained group subjects at the end of an acute bout of physical exercise as compared to their basal levels. There was a significant (p<0.05) increase in 1-hour post exercise serum vitamin E levels in trained control group (A and B) subjects as compared to their immediate post exercise levels. However, no such increase was found in untrained test group (C and D) subjects whose 1-hour post exercise serum vitamin E levels remained almost the same as compared with their immediate post exercise levels. CONCLUSION: Exercise-training results in decreased 1-hour post-exercise serum Malondialdehyde and an increase in 1-hour post-exercise serum vitamin E levels as compared to their immediate post exercise levels in physically trained healthy people in comparison to untrained apparently healthy people. It can be therefore concluded that exercise training results in more increased mobilization of vitamin E from its depots after exercise than in untrained healthy people.

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