M H Osmani, Shabnam, Farqqqui.
Role of Cyclosporin Monotherapy in Nephrotic Syndrome.
J Surg Pak Jan ;6(2):26-8.

A prospective study on Role of Cyclosporin Monotherapy in Nephrotic Syndrome was carried out from January -June 2001 at Jinnah Postgraduate Medical Centre, Karachi. Twenty-flue patients suffering from nephrotic syndrome (15 males and 10 females, ages 8 to 50 years), were given a moderate dose of cyclosporin. Renal biopsies `were performed in all cases. Two had minimal change, eight mesangioproliferative glomerulonephritis (MPGN); nine focal segmental glomerulosclerosis (FSGS) and six membranous nephropathy had received past treatment with steroid, cyclophosphamide and/or combination. Most of these patients were steroid-dependent, steroid-resistant, frequent relapsers, and non-responders. Cyclosporin in the form of Consupren was prescribed in doses 3 to 5 mg/kg body weight and toxicity was monitored closely by trough level estimation of cyclosporin. Results show, that OS patients are in remission, 13 in partial remission, and 04 have not yet responded. No toxicity was encountered in this short duration study. These findings suggest that cyclosporin monotherapy may be useful in nephrotic syndrome patients in whom steroids and alkylating agents may have failed or are contraindicated.

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