Manan Junejo.
Lupus nephritis: clinicopathological correlation.
J Surg Pak Jan ;11(1):20-3.

Objective: To analyze clinicopathological correlation in lupus nephritis (LN). Design: Analytical study Place and duration of Study: Two years (January 2002 to December, 2004) study conducted at the Department of Nephrology, Jinnah Postgraduate Medical Centre, Karachi. Patients & Methods: Thirty patients of both sexes between ages of 15 - 70 years, fulfilling criteria of primary SLE and with renal impairment were included in the study. Various investigations like complete blood picture, blood urea nitrogen (BUN), serum creatinine, 24 hours urinary protein, creatinine clearance, ANA, double stranded DNA (Anti Ds DNA), ultrasound of kidneys were carried out. Ultrasound guided renal biopsy was done in all cases. Results: Proteinuria was found in all 30 cases, nephrotic syndrome in 18 (60%) patients, oliguria in 17 (56.60%), microscopic hematuria in 20 (66.60%) and hypertension in 21 (70%) cases. Various clinical features of SLE including arthritis in 20 (66%), arthralgia 26 (86.60%), serositis 7 (23%) and anemia in 20 (66.6%) cases. Renal biopsy results were classified according to WHO criteria and it revealed that 16.70% has mesangial proliferation, 20% had focal proliferation, 40% showed diffuse proliferation, 16.70% membranous type and 6.70% had advanced sclerosis. Conclusions: Whenever a patient, especially young female, presents with proteinuria and haematuria with RBCs cast, lupus nephritis should be suspected. If it is proved then renal biopsy should be done to classify into either mild lesion (class-11 or V) or severe lesions (class-III or IV). The findings of renal biopsy can help in planning appropriate management of the patients.

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