Imdad Hussain, Syed Qaisar Naqvi, Qammar Jamal, Waheeduz Zaman Tariq, Faizuddin, Abrar Shaikh, Aziz Merjan.
HER-2/NEU oncoprotein: A biomarker in human prostate cancer.
Pak J Pathol Jan ;16(2):61-4.
Objective: To determine the frequencies of HER-2/neu overexpression in prostate adenocarcinoma. Design: A retrospective study of 50 patients suffering from prostate adenocarcinoma. Setting: BMSI, Jinnah Post Graduate Medical Centre Karachi 1999-2001. Subjects: Fifty patients between the ages of 50-80 years were selected during period 1990-2001 having prostate carcinoma. Results: Maximum numbers of tumour among total cases were in age group ranging from 51-60 years i.e.13 tumours (26% of total cases). Frequency of HER/2neu expression was found to be 12%. All the positive cases were poorly differentiated with Gleason score 8-10. Conclusions: HER-2/neu overexpression was present in 12% of prostatic adenocarcinoma cases. Specific therapeutic targeting of these neoplasms may be accomplished with (Herceptin), which may reveal a new treatment option.
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