Nouf Al Hammad.
Efficacy of peripheral glycerol injection in the management of trigeminal neuralgia.
Pak Oral Dental J Jan ;26(1):93-6.

To evaluate the degree and duration of pain relief obtained with peripheral glycerol injection in patients with idiopathic trigeminal neuralgia. Interventional, Clinical trial. Fifty (50) medically resistant and non-surgically treated patients were selected. In the study group twenty five (25) patients received 1 ml glycerol injections in the involved peripheral nerve, after administration of local anaesthesia. The control group of twenty five (25) patients received 1 ml normal saline injections. All the patients (25) in the control group (normal saline) had no pain relief. Out of the 25 patients who received glycerol injections 24 (96%) patients had pain relief for 3 months. At six months nineteen (76%) patients had pain relief. At one-year follow up eleven patients (44%) continued to have pain relief. Another eleven (44%) patients were pain free with minimal dose of medication. There were no significant complications reported after the glycerol injections. The combination of efficacy and decreased morbidity makes peripheral glycerol injections a useful treatment modality for medically intractable Trigeminal Neuralgia patients.

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