Uzma Hashami, Sadia Subohi.
Prophylactic use of Oxytocin versus Oxytocin plus Ergometrin for preventic of post-partum hemorrhage.
J Surg Pak Jan ;11(2):56-8.

Objective: To assess the effects of oxytocin (Syntocinon) versus oxytocin plus ergometrin (Syntometrin) in reducing the risk of post partum haemorrage and to find out their side effects. Design: Comparative analytical study Place and Duration of Study: The study was performed at Jinnah Postgraduate Medical Centre, in the Department of Gynaecology & Obstetrics over a period of one year from January 2002 to December 2002. Patient and Methods: Three hundred patients were selected by non-probability convenience sampling. This study was conducted on the patients admitted in labour room with singleton pregnency in whom vaginal delivery was imminent. The patients were grouped in three categories. The group comprised of 150 patients who received injection oxytocin 5 unit I/ V alone. The group II comprised of 150 patients who received injection oxytocin 5 unit & injection ergometrin 0.5mg. I/M. The injections were given after expulsion of placenta. Blood loss during delivery was estimated by measuring the amount of blood clots and weighing the towels and swabs soaked before and after delivery. Any delayed haemorrhage within in the first 24 hours after delivery was also recorded. Maternal blood pressure was measured immediately after delivery. The side effects like nausea, vomiting and headache were noted from time ranging _-1 hour after delivery. Data was analyzed using SPSS version 10. Results: The rate of 46.7% of blood loss of 500m1 in syntocinon group was observed significantly high as compared to that of 36.7% of syntometrin ( p 0.05). The rate of adverse effects in group I was 8% and 17.3% in group H. The data revealed a significantly high rate (2=2.39 P=0.008) of adverse effects in group II patients than group I (p 0.05). Conclusion: Oxytocin alone is as effective as the use of oxytocin plus ergometrin in the prevention of post partum haemorrhage and is associated with significantly fewer maternal side effects.

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