Asma Batool, Durre Samin Akram, Fehmina Arif.
Changing antibiotic sensitivity of organisms causing neonatal sepsis: A hospital based study.
Pak Paed J Jan ;29(2):57-61.

Septicemia is an important cause of morbidity and mortality in neonates. A study was done at Neonatal Intensive Care Unit, Pediatrics Unit I, Dow University of Health Sciences and Civil Hospital Karachi, to study pattern of infection in neonatal sepsis and drug sensitivity. Results were compared with a similar study in this unit during 1984-85. During nine months (July 2001- March 2002) 181 clinically suspected cases of neonatal septicemia were investigated by performing blood culture. One hundred cases were found to have positive blood cultures. Klebsiella was the commonest organisms (24%) followed by Staphylococcus aureus coagulase +ve (22%), Pseudomonas (20%), Enterobacter (9%) and E.coli (9%). No Group B Streptococcus was isolated. The mean sensitivity to ampicillin was 13%, 34% to tobramycin, 39% to gentamicin and 35% to cefotaxime. Although the spectrum of organisms was similar to that studied twenty years prior in the same environment, the sensitivity pattern had dramatically changed. This study highlights the need for repeated surveillance of organisms responsible for neonatal sepsis and their sensitivity to antibiotics which could help in reducing morbidity and mortality in neonates.

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